M. Guo

KLF6 in Pulmonary Hypertension: The Dual Role of Friend and Foe

This study identifies KLF6 as a key driver of endothelial dysfunction in pulmonary arterial hypertension, showing its role in promoting vascular remodelling and angioproliferative lesions.

Chromosome-level genome assembly of autotetraploid Selenicereus megalanthus and gaining genomic insights into the evolution of trait patterning in diploid and polyploid pitaya species

Patho-transcriptomic analysis of invasive mucinous adenocarcinoma of the lung (IMA): comparison with lung adenocarcinoma with signet ring cell features (SRCC)

This study compares the patho-transcriptomic profiles of invasive mucinous adenocarcinoma (IMA) and adenocarcinoma with signet ring cell features (SRCC), identifying distinct and shared gene expression patterns and potential therapeutic targets.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

Adapting C4 photosynthesis to atmospheric change and increasing productivity by elevating Rubisco content in Sorghum and Sugarcane

This paper shows that increasing Rubisco content in sorghum and sugarcane through genetic modification improves photosynthetic efficiency and productivity, with field and greenhouse trials showing biomass increases of 15.5% and 37-81% respectively.

Nuclear size-regulated emergence of topological packing order on growing human lung alveolospheres

This study shows that cell packing order in human lung alveolospheres increases with nucleus-to-cell size ratio, resembling a gas-to-liquid transition, and may regulate organ development and maturation.

Three-dimensional spatio-angular fluorescence microscopy with a polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM)

The paper introduces a polarized dual-view light-sheet microscope to recover 3D orientations and positions of fluorescent dipoles, validated with experiments on biological samples.

Engineering customized viral receptors for various coronaviruses

This paper develops a method to engineer customized viral receptors (CVRs) for various coronaviruses, enabling infection models for viruses lacking known receptors.

Phase diversity-based wavefront sensing for fluorescence microscopy

This paper introduces a phase diversity-based wavefront sensing method for fluorescence microscopy to correct optical aberrations efficiently and accurately.

Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy

This paper introduces a deep learning method to correct optical aberrations in fluorescence microscopy, improving image quality and enabling better downstream analysis.

Polymerization force-regulated actin filament-Arp23 complex interaction dominates self-adaptive cell migrations

This study develops a multiscale model showing that polymerization force-regulated actin-Arp2/3 interactions enable cells to adaptively migrate through heterogeneous ECMs via opposing feedback mechanisms.

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

Reproductive sexual dimorphisms in two willow species, Salix exigua Nutt. and S. nigra Marshall.

The paper examines reproductive sexual dimorphisms in two willow species, finding males produce more flowers per catkin and catkins per branch than females.

Molecular, metabolic and functional CD4 T cell paralysis impedes tumor control

This study identifies mechanisms by which CD4 T cell paralysis impairs tumor control by stalling proliferation and differentiation through Treg and CTLA4 signaling interactions.

ANKRD49 promotes the metastasis of NCI-H1299 and NCI-H1703 cells via activating JNK-ATF2/c-Jun-MMP-2/9 axis

This study shows ANKRD49 promotes metastasis in NSCLC cells by activating the JNK-ATF2/c-Jun-MMP-2/9 pathway.

Three-dimensional structured illumination microscopy with enhanced axial resolution

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

Species-specific roles for the MAFA and MAFB transcription factors in regulatingislet β cell identity

The paper investigates the species-specific roles of MAFA and MAFB in maintaining β cell identity, showing MafA in mice and MAFB in humans repress non-β cell hormones like GAST.

Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive Cells

This study identifies PBX1 as a critical regulator of LAM progression by analyzing scRNA-seq data and validating its role in LAM cell survival and lung colonization.

Dysregulation of Acid Ceramidase-mediated Sphingolipid Metabolism Contributes to Tumor Progression in Tuberous Sclerosis Complex

This study identifies dysregulated sphingolipid metabolism in TSC2-null cells and tumors, showing that ASAH1 inhibition reduces cell viability and tumor growth in TSC and LAM.

Guild-level microbiome signature associated with COVID-19 severity and prognosis

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT

This study determines the cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP complexed with TPR-CHAT and target RNA, revealing its mechanism of RNA recognition and cleavage.

Recovery of structural integrity of epithelial monolayer in response to massive apoptosis-induced defects

This study shows that epithelial monolayers recover structural integrity after apoptosis-induced defects through enhanced cell spreading, migration, and traction forces.

Comprehensively characterizing evolutionarily conserved differential dosage compensations of the X chromosome during development and in diseases

The paper identifies two X gene groups with distinct dosage compensations during development and in diseases, and discovers new regulators of X dosage compensation.

Chemical structures of cyclic ADP ribose (cADPR) isomers and the molecular basis of their production and signaling

The paper reports the chemical structures of two cADPR isomers, their production mechanism, and their roles in antiviral signaling and plant immunity suppression.

Microfluidic chemostatic bioreactor for high-throughput screening and sustainable co-harvesting of biomass and biodiesel in microalgae

This paper develops a microfluidic chemostatic bioreactor for high-throughput screening of microalgal growth and lipid production, achieving higher throughput and efficiency compared to traditional methods.

The tissue-specific chromatin accessibility landscape of Papaver somniferum

This study identifies tissue-specific chromatin accessibility and gene expression in Papaver somniferum to uncover regulatory mechanisms for morphine and noscapine accumulation.

Vimentin Intermediate Filaments Can Enhance or Abate Active Cellular Forces in a Microenvironmental Stiffness-Dependent Manner

This study shows vimentin intermediate filaments modulate cell-generated forces depending on microenvironment stiffness, increasing forces on stiff matrices and decreasing them on soft matrices.

An integrated cell atlas of the human lung in health and disease

The paper integrates 46 single-cell datasets to create the Human Lung Cell Atlas, improving cell annotation and uncovering gene modules linked to demographics and anatomy.

Incorporating the image formation process into deep learning improves network performance in deconvolution applications

This paper introduces RLN, a deep learning method for 3D fluorescence microscopy deconvolution that improves speed, performance, and generalizability compared to existing methods.

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.