Autoimmunity Risk Gene IRGM is a Master Negative Regulator of Interferon Response by Controlling the Activation of cGAS STING and RIG-I-MAVS Signaling Pathways
K. K. Jena, S. Mehto, P. Nath, N. R. Chauhan, R. Sahu, T. K. Nayak, S. K. Das, K. Dhar, P. K. Sahoo, K. C. Murmu, S. De, A. Datey, P. Prasad, S. Chattopadhyay, S. Chauhan, S. Chauhan
This study identifies IRGM as a negative regulator of interferon response by controlling cGAS-STING and RIG-I-MAVS pathways, linking its deficiency to autoimmunity and antiviral resistance.
bioRxiv · Oct 22, 2019 · PreprintImmunology