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Curtailed CaSR expression in peripheral blood mononuclear cells is associated with hypertension

The paper investigates reduced CaSR expression in hypertensive models and links it to impaired NO production and altered Ca2+ dynamics.

E-proteins set the threshold for optimal TCF1 expression during αβ T cell development.

This study shows E-proteins regulate TCF1 expression thresholds during T cell development, with EPE3 being critical for TCF1 levels and T cell differentiation.

Transcription factor TFII-I fine tunes innate properties of B lymphocytes

This study shows that TFII-I is essential for maintaining innate B cell properties, with its loss causing myeloid-like transcriptomic changes and increased IgG3 switching.

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

This study identifies the YAP-TEAD pathway as a target for senolytic therapy, showing that inhibiting it induces apoptosis in senescent cells by increasing ER stress.

The Radiogenomic and Spatiogenomic Landscapes of Glioblastoma, and Their Relationship to Oncogenic Drivers

This study identifies imaging and spatial biomarkers in glioblastoma that correlate with molecular features and oncogenic drivers using machine learning on MRI data.

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

This study investigates BAFF's role in senescence by showing its cell-type-specific effects on SASP and growth arrest.

DNA damage response signaling is crucial for effective Chikungunya virus replication

This study shows that Chikungunya virus (CHIKV) infection activates DNA damage response (DDR) pathways, increases DNA damage, and interacts with Chk2 and Chk1 to facilitate viral replication and cell cycle arrest.

Single-cell analysis of skeletal muscle macrophages reveals age- associated functional subpopulations

This study identifies age-associated functional subpopulations of skeletal muscle macrophages using single-cell transcriptomics in mice.

KMT2C deficiency promotes APOBEC mutagenesis and genomic instability in multiple cancers

This study shows KMT2C deficiency increases APOBEC mutagenesis and genomic instability in multiple cancers by impairing DNA replication and promoting APOBEC activity.

Isolation and Characterization of SARS-CoV-2 strains circulating in Eastern India.

The paper isolates and characterizes five SARS-CoV-2 strains from India, showing variations in cytotoxicity and cell line permissiveness, and finds both Covaxin and Covishield vaccines neutralize all isolates effectively.

Telmisartan restricts Chikungunya virus infection in vitro and in vivo through the AT1/ PPAR-γ/MAPKs pathways

This study shows Telmisartan reduces Chikungunya virus infection in vitro and in vivo by modulating host pathways including AT1/PPAR-γ/MAPKs.

MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway

This study shows that MK2 and MK3 inhibition with CMPD1 reduces CHIKV infection by blocking actin remodeling and viral release, with potential for antiviral development.

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer's R47H mutant does the opposite

The paper shows wild-type sTREM2 inhibits Aβ aggregation and neurotoxicity, while the R47H variant promotes Aβ aggregation and neurotoxicity.

Fast 3D imaging of giant unilamellar vesicles using reflected light-sheet microscopy with single molecule sensitivity

The paper develops a reflected light-sheet microscope with active optics for fast, high-contrast, two-color imaging of GUVs at the single-molecule level.

A Novel Model of Pancreatic Cancer Dormancy Reveals Mechanistic Insights and a Dormancy Gene Signature with Human Relevance

This study introduces a novel pancreatic cancer dormancy model, identifies a dormancy gene signature, and reveals mechanisms including chromatin remodeling and CCL5 as a novel marker.

Origin and Evolution of DNA methyltransferases (DNMT) along the tree of life: A multi-genome survey.

This study systematically surveys the evolution of DNA methyltransferases across different lineages, finding increased sequence conservation and complexity in vertebrates.

Autoimmunity Risk Gene IRGM is a Master Negative Regulator of Interferon Response by Controlling the Activation of cGAS STING and RIG-I-MAVS Signaling Pathways

This study identifies IRGM as a negative regulator of interferon response by controlling cGAS-STING and RIG-I-MAVS pathways, linking its deficiency to autoimmunity and antiviral resistance.

Non-genetic intra-tumor heterogeneity is a major predictor of phenotypic heterogeneity and ongoing evolutionary dynamics in lung tumors

The paper examines non-genetic intra-tumor heterogeneity in lung tumors, finding it significantly influences phenotypic diversity and evolutionary dynamics beyond genetic factors.

Performance evaluation of biosurfactant stabilized microbubbles in enhanced oil recovery

This study evaluates biosurfactant-stabilized microbubbles for tertiary oil recovery, finding they achieve higher oil recovery (46%) than aqueous biosurfactant solutions (36%) with lower pressure requirements.

Respiratory heterogeneity shapes biofilm formation and host colonization in uropathogenic Escherichia coli

This study shows that respiratory heterogeneity in uropathogenic E. coli influences biofilm formation and host colonization through differential expression of cytochrome oxidases.

The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from transcription sites

This study shows UPF1 associates with nascent RNAs in the nucleus and is required for mRNA release from transcription sites in Drosophila.