ImmunologybioRxivPreprint
Autoimmunity Risk Gene IRGM is a Master Negative Regulator of Interferon Response by Controlling the Activation of cGAS STING and RIG-I-MAVS Signaling Pathways
K. K. Jena, S. Mehto, P. Nath…·S. Chauhan
This study identifies IRGM as a negative regulator of interferon response by controlling cGAS-STING and RIG-I-MAVS pathways, linking its deficiency to autoimmunity and antiviral resistance.
DOI 10.1101/815506