A. Datey

Yeast eukaryotic initiation factor 4B remodels the mRNA entry site on the small ribosomal subunit

This study uses cryo-electron microscopy to determine the position of yeast eIF4B on the 40S ribosomal subunit and its role in mRNA recruitment.

DNA damage response signaling is crucial for effective Chikungunya virus replication

This study shows that Chikungunya virus (CHIKV) infection activates DNA damage response (DDR) pathways, increases DNA damage, and interacts with Chk2 and Chk1 to facilitate viral replication and cell cycle arrest.

Isolation and Characterization of SARS-CoV-2 strains circulating in Eastern India.

The paper isolates and characterizes five SARS-CoV-2 strains from India, showing variations in cytotoxicity and cell line permissiveness, and finds both Covaxin and Covishield vaccines neutralize all isolates effectively.

A novel innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins

The paper identifies a novel innate pathogen sensing strategy through ubiquitination of bacterial surface proteins, revealing a conserved mechanism for pathogen detection and clearance.

Telmisartan restricts Chikungunya virus infection in vitro and in vivo through the AT1/ PPAR-γ/MAPKs pathways

This study shows Telmisartan reduces Chikungunya virus infection in vitro and in vivo by modulating host pathways including AT1/PPAR-γ/MAPKs.

MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway

This study shows that MK2 and MK3 inhibition with CMPD1 reduces CHIKV infection by blocking actin remodeling and viral release, with potential for antiviral development.

Molecular epidemiology of Japanese Encephalitis Virus in pig population of Odisha, Assam and Manipur states of India

This study investigates JEV prevalence and molecular epidemiology in pigs from three Indian states, finding higher infection rates in Manipur and identifying genotype III as dominant with specific mutations.

Autoimmunity Risk Gene IRGM is a Master Negative Regulator of Interferon Response by Controlling the Activation of cGAS STING and RIG-I-MAVS Signaling Pathways

This study identifies IRGM as a negative regulator of interferon response by controlling cGAS-STING and RIG-I-MAVS pathways, linking its deficiency to autoimmunity and antiviral resistance.

A simple method to determine the elimination half-life of drugs displaying noncumulative toxicity

This paper introduces TOXHL, a method to determine the elimination half-life of drugs with noncumulative toxicity using survival outcomes from three experiments.