Cancer BiologybioRxivPreprint
Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer
L. K. Godfrey, J. Forster, S.-T. Liffers…·J. T. Siveke
This study identifies adaptive DNA methylation changes and clonal expansion as mechanisms of resistance to MEKi in PDAC, showing reversibility upon drug withdrawal.
DOI 10.1101/2022.05.20.492826