Author

B. Sitek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

T. Bracht· 4 shared M. Trilling· 3 shared V. T. K. Le-Trilling· 3 shared M. Eisenacher· 2 shared A. Belter· 1 shared A. Dixit· 1 shared A. Graziadei· 1 shared A. Krawczyk· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersImmunology

T. Bracht

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T-cell recognition by targeting CIITA

F. Maassen, V. T. K. Le-Trilling, L. Betke, T. Bracht, C. Schuler, M. Bayer, A. Belter, T. Becker, B. Katschinski, L. Frappier, B. Sitek, K. Fleischhauer, M. Trilling

This study identifies pUS28 as a viral protein that inhibits CIITA-driven HLA-II expression, thereby blocking CD4+ T-cell recognition of HCMV-infected cells.

bioRxiv · Oct 17, 2023 · PreprintImmunology

Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer

L. K. Godfrey, J. Forster, S.-T. Liffers, C. Schroeder, J. Koester, L. Henschel, K. U. Ludwig, M. Trajkovic-Arsic, D. Behrens, A. Scarpa, R. T. Lawlor, K. E. Witzke, B. Sitek, S. A. Johnsen, S. Rahmann, , J. T. Siveke

This study identifies adaptive DNA methylation changes and clonal expansion as mechanisms of resistance to MEKi in PDAC, showing reversibility upon drug withdrawal.

bioRxiv · May 20, 2022 · PreprintCancer Biology

Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism

V. T. K. Le-Trilling, S. Banchenko, D. Paydar, P. M. Leipe, L. Binting, S. Lauer, A. Graziadei, C. Gotthold, J. Burger, T. Bracht, B. Sitek, R. J. Lebbink, A. Malyshkina, T. Mielke, J. Rappsilber, , D. Schwefel

This study identifies E27 as a viral protein that targets STAT2 for degradation via CRL4 ubiquitin ligases, revealing its structural mechanism of interferon antagonism.

bioRxiv · May 5, 2022Biochemistry

An increase in surface hydrophobicity mediates chaperone activity in N-chlorinated proteins

M. Varatnitskaya, J. Fasel, A. Müller, N. Lupilov, Y. Shi, K. Fuchs, M. Krewing, C. Jung, T. Jacob, B. Sitek, J. E. Bandow, K. S. Carroll, L. I. Leichert

This study identifies specific chlorinated residues in RidA that are critical for its chaperone activity under oxidative stress.

bioRxiv · Oct 26, 2021Biochemistry

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection

J. Schuhenn, T. L. Meister, D. Todt, T. Bracht, K. Schork, J.-N. Billaud, C. Elsner, N. Heinen, Z. Karakoese, S. Haid, S. Kumar, L. Brunotte, M. Eisenacher, J. Chen, Z. Yuan, , S. Pfaender

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

bioRxiv · May 20, 2021 · PreprintCell Biology

Relocation of macrophages maintains the barrier function of the urothelium and protects against persistent infection

J. Bottek, C. Soun, J. K. Volke, A. Dixit, S. Thiebes, A.-L. Beerlage, M. Horstmann, A. Urbanek, J. Uszkoreit, M. Eisenacher, T. Bracht, B. Sitek, F. Hoffmann, N. Vijitha, F. von Eggeling, D. R. Engel

The paper shows that macrophage relocation into the urothelium, driven by IL-6 and CX3CL1, helps maintain barrier function and prevent recurrent urinary tract infections.

bioRxiv · Jun 6, 2019 · PreprintImmunology