S. Bhatia

Phenotypic screens identify biologic regulators of nanoparticle uptake in diffuse midline glioma

The paper identifies biologic regulators of nanoparticle uptake in diffuse midline glioma using CRISPR screens and functional assays, finding CTNNB1 and pathway members as key modulators.

Development of a Bipyrimidineamide based α-Helix Mimetic Lead Compound for efficient Targeting of MDM2 in Triple-Negative Breast Cancer

This study develops a bipyrimidineamide-based α-helix mimetic compound, VWK603, which effectively targets MDM2 in TNBC cells with lower toxicity than Nutlin-3a.

Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in India

This study identifies mutations in H5N1 avian influenza viruses that confer resistance to neuraminidase inhibitors, revealing their molecular mechanisms and implications for antiviral strategies.

The mycotoxin Beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway

This study identifies Beauvericin as an activator of dendritic cells via the TLR4 signaling pathway, suggesting its potential as a vaccine adjuvant or cancer immunotherapy.

Multiscale profiling of enzyme activity in cancer

This paper develops methods to measure enzyme activity in cancer across multiple scales, revealing protease dysregulation and dynamic interactions between tumor cells and their microenvironment.

Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics

This study develops and characterizes patient-derived TNBC organoids that recapitulate tumor properties and identify key signaling pathways involved in cancer progression.

Natural infection of SARS-CoV-2 delta variant in Asiatic lions (Panthera leo persica) in India

The paper reports the detection of SARS-CoV-2 delta variant in Asiatic lions in India and its genetic similarity to local human isolates.

PHAROH lncRNA regulates c-Myc translation in hepatocellular carcinoma via sequestering TIAR

The paper identifies PHAROH, an lncRNA overexpressed in hepatocellular carcinoma, which regulates c-Myc translation by sequestering TIAR, impacting cell proliferation and migration.

CRISPR-Cas-amplified urine biomarkers for multiplexed and portable cancer diagnostics

This paper develops CRISPR-Cas-amplified urine biomarkers for noninvasive cancer detection and monitoring in murine models.

Healing Tissues From the Inside Out: Infusible Biomaterial for Targeting and Treating Inflammatory Tissues via Intravascular Administration

This study develops a new ECM therapy for intravascular infusion to target and treat inflammatory tissues, showing improved tissue repair and reduced inflammation in animal models of MI and other injuries.

MaTAR25 LncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression

This study identifies MaTAR25 and its human ortholog LINC01271 as lncRNAs that regulate Tns1 expression, impacting breast cancer progression through actin cytoskeleton and focal adhesion changes.

Identification of miRNAs and their corresponding mRNA targets from chickpea nodules and functional characterization of candidate miRNAs by overexpression in chickpea roots

The paper identifies miRNAs and their mRNA targets in chickpea nodules and functionally characterizes selected miRNAs through overexpression in chickpea roots, revealing novel miRNA-target pairs and bacterial-derived small RNAs.

Three complete genome sequences of Penguin megrivirus from ornithogenic soil, Adelie penguin and Weddell seal of Antarctica

The paper reports three complete genome sequences of Penguin megriviruses from Antarctic sources and shows their phylogenetic similarity.

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

This study characterizes treatment-induced high-grade gliomas (TIHGGs) through molecular profiling, identifying distinct subgroups and potential therapeutic targets.

Identification of a novel tetrameric structure for human apolipoprotein-D

This study identifies a tetrameric structure of human apolipoprotein-D in breast cyst fluid, contrasting with its monomeric or higher-order forms in other biological fluids.