Leukocyte-derived High-mobility group box 1 controls innate immune responses against Listeria monocytogenes.
A. Volmari, K. Foelsch, K. Yan, M. Qi, K. Bartels, S. Kondratowicz, M. Boettcher, M. Nishibori, K. Liu, R. F. Schwabe, A. W. Lohse, S. Huber, H.-W. Mittruecker, P. Huebener
This study shows that HMGB1 from leukocytes is critical for immune responses against Listeria monocytogenes, while hepatocyte HMGB1 is not essential for moderate infections but may contribute to excessive inflammation in severe cases.
bioRxiv · Oct 8, 2019 · PreprintImmunology