S. Huber

Snapshots of Pseudomonas aeruginosa SOS response activation complex reveal structural prerequisites for LexA engagement and cleavage

This study reveals the structural basis of RecA-LexA interaction in Pseudomonas aeruginosa, showing how RecA triggers LexA cleavage and inactivation, which is critical for the SOS response.

Single-nucleotide-resolution genomic maps of O6-methylguanine from the glioblastoma drug temozolomide

This paper introduces O6-MeG-seq, a method to map O6-methylguanine at single-nucleotide resolution, and shows MGMT does not preferentially repair O6-MeG based on sequence context or chromatin state.

Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

The paper shows mitochondrial dysfunction in intestinal epithelium leads to microbiota-dependent injury and identifies gene signatures that distinguish active from inactive inflammation in IBD.

Emergence and suppressive function of Tr1 cells in glomerulonephritis

This study identifies Tr1 cells in glomerulonephritis, showing their suppressive function and potential as therapeutic targets.

Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling

The paper shows that liver injury suppresses systemic T cell immunity to viral infection, which can be reversed by inhibiting interferon and IL-10 signaling in preclinical models and human patients.

Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 reveal a novel binding site for positive modulators

The paper determines high-resolution Cryo-EM structures of the human Kv3.1 channel, both apo and ligand-bound, revealing a novel binding site for positive modulators.

Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression

This study shows that blocking peripheral sgp130-mediated trans-signaling in mice causes obesity and insulin resistance by suppressing PPARα.

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency

The paper identifies IL6 trans-signaling as a mechanism supporting DCC survival and outgrowth during clinical latency, with microenvironmental dependencies and PIK3CA mutations linked to metastatic progression.

Marriage in the Melting Pot: An evolutionary approach to European ancestry, homogamy and fertility in the United States

The paper examines ancestral homogamy, fertility, and heritability of marriage behavior in US women using census data and mixed models.

Leukocyte-derived High-mobility group box 1 controls innate immune responses against Listeria monocytogenes.

This study shows that HMGB1 from leukocytes is critical for immune responses against Listeria monocytogenes, while hepatocyte HMGB1 is not essential for moderate infections but may contribute to excessive inflammation in severe cases.

Increased temperatures may safeguard the nutritional quality of crops under future elevated CO2 concentrations

This study shows that elevated CO2 reduces iron and zinc in soybean seeds, but higher temperatures counteract this effect, potentially mitigating nutritional risks.

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

This study elucidates the allosteric mechanism of HtrA1 activation through inter-monomer communication, showing its role in proteolytic activity and disease-related pathologies.