R. F. Schwabe

This study identifies TILAM, a conserved lncRNA that promotes liver fibrosis by interacting with PML in HSCs, and shows its depletion reduces fibrosis in mouse models.

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

This study shows that nuclear HMGB1 suppresses liver lipogenesis in NAFLD by inhibiting LXR activity, preventing steatosis and insulin resistance.

This study shows that HMGB1 from leukocytes is critical for immune responses against Listeria monocytogenes, while hepatocyte HMGB1 is not essential for moderate infections but may contribute to excessive inflammation in severe cases.