K. Forchhammer

Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signalling cascade

The paper investigates the role of c-di-AMP and SbtB in cyanobacterial diurnal metabolism, finding that their disruption leads to metabolic dysregulation and diurnal lethality.

PII signal transduction superfamily acts as a valve plug to control bicarbonate and ammonia homeostasis among different bacterial phyla

The paper identifies SbtB as a PII-like protein that acts as a unidirectional valve to control bicarbonate transport via SbtA in cyanobacteria, with similar mechanisms observed in Bacillus for ammonium transport.

Redox control and substrate specificity of the glycogen catabolic isoenzymes in Synechocystis sp. PCC 6803

This study investigates redox regulation and substrate specificity of glycogen catabolic isoenzymes in Synechocystis sp. PCC 6803, revealing redox control of GlgP1 and functional differences between GlgX1 and GlgX2.

Glucose-1,6-bisphosphate, a key metabolic regulator, is synthesized by a distinct family of α-D-phosphohexomutases widely distributed in prokaryotes

This study identifies Slr1334 as a Glc-1,6-BP-synthase in cyanobacteria and shows its conserved function in human gut bacteria.

Phosphorylation of phosphoglucomutase 1 on a peripheral site tunes its activity to regulate glycogen metabolism.

This study identifies phosphorylation of PGM1 at Ser 47 as a conserved regulatory mechanism controlling glycogen metabolism in Synechocystis during nitrogen starvation.

5-Deoxyadenosine Salvage by Promiscuous Enzyme Activity leads to Bioactive Deoxy-Sugar Synthesis in Synechococcus elongatus

The paper identifies a novel 5-deoxyadenosine salvage pathway in Synechococcus elongatus that produces the bioactive deoxy-sugar 7-deoxysedoheptulose through promiscuous enzyme activity.

The essential role of sodium bioenergetics and ATP homeostasis in the developmental transitions of a cyanobacterium

This study investigates ATP homeostasis in Synechocystis during nitrogen starvation and recovery, showing sodium bioenergetics and glycogen catabolism are critical for maintaining and restoring ATP levels.

The novel PII-interacting protein PirA regulates flux into the cyanobacterial ornithine-ammonia cycle

This paper identifies PirA, a novel PII-interacting protein that regulates flux into the cyanobacterial ornithine-ammonia cycle by competing with NAGK for PII binding, thereby affecting arginine synthesis and nitrogen storage.

Maximizing PHB content in Synechocystis sp. PCC 6803: development of a new photosynthetic overproduction strain.

This paper develops a new Synechocystis sp. PCC 6803 strain that overproduces PHB up to 81% CDW by modifying regulatory and metabolic genes.

The Novel PII-Interacting Regulator PirC (Sll0944) Identifies 3-Phosphoglycerate Mutase (PGAM) as Central Control Point of Carbon Storage Metabolism in Cyanobacteria

This study identifies PirC as a PII-interacting regulator that inhibits PGAM, controlling carbon flux towards glycogen or polyhydroxybutyrate in cyanobacteria under nitrogen limitation.

Long-range quantum coherence of the photosystem 2 complexes in living cyanobacteria

The paper observes vacuum Rabi splitting in cyanobacteria, indicating long-range quantum coherence in photosystem 2 complexes that contributes to high energy transfer efficiency.

A novel Ca2+-binding protein influences photosynthetic electron transport in Anabaena sp. PCC 7120

The paper identifies a novel calcium-binding protein, CSE, in Anabaena sp. PCC 7120 and shows its role in photosynthetic electron transport by altering protein complexes and respiration.

Structure and function of a bacterial gap junction analog

The paper resolves the structure of bacterial septal junctions and shows they gate intercellular communication through conformational changes mediated by proteins FraC/D.

Chlorosis as a developmental program in cyanobacteria: the proteomic fundament for survival and awakening

The paper uses proteomics to study the transition of cyanobacteria from a dormant chlorotic state to vegetative growth, identifying key protein modifications and their roles in survival.