Author

W.-T. Hou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 3 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

C.-Z. Zhou· 4 shared Y. Chen· 3 shared L. Wang· 2 shared D. Xu· 1 shared K. A. Selim· 1 shared K. Forchhammer· 1 shared K. Hauf· 1 shared K. Xu· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

C.-Z. Zhou

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PII signal transduction superfamily acts as a valve plug to control bicarbonate and ammonia homeostasis among different bacterial phyla

M. Haffner, W.-T. Hou, O. Mantovani, P. R. Walke, K. Hauf, M. Borisova, M. Hagemann, C.-Z. Zhou, K. Forchhammer, K. A. Selim

The paper identifies SbtB as a PII-like protein that acts as a unidirectional valve to control bicarbonate transport via SbtA in cyanobacteria, with similar mechanisms observed in Bacillus for ammonium transport.

bioRxiv · Aug 10, 2023 · PreprintMicrobiology

Structural insights into human ABCC4 mediated transport of platelet agonist and inhibitor

Y. Chen, L. Wang, W.-T. Hou, Z.-H. Zha, K. Xu, C.-Z. Zhou, Q. Li, Y. Chen

This study determines the structures of human ABCC4 in apo and complexed forms, revealing its role in exporting platelet agonists and inhibitors, and identifying a pocket for drug design.

bioRxiv · Dec 25, 2022 · PreprintBiochemistry

Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding

M.-T. Cheng, Y. Chen, Z.-P. Chen, C.-Z. Zhou, W.-T. Hou, Y. Chen

This study reveals the structural mechanism of ATP8B1 activation by substrate binding, showing an autoinhibited state that is released upon phosphatidylserine binding.

bioRxiv · Nov 7, 2021Biochemistry

Structural basis of substrate recognition and translocation by human ABCD1

Z. Chen, D. Xu, L. Wang, C.-Z. Zhou, W.-T. Hou, Y. Chen

This paper reports cryo-EM structures of human ABCD1 in different states to elucidate its mechanism of substrate recognition, translocation, and release.

bioRxiv · Sep 24, 2021Biophysics