Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: induction of autoimmunity and tumor immunity by disrupting the association
K. Ichiyama, J. Long, Y. Kobayashi, Y. Horita, T. Kinoshita, Y. Nakamura, C. Kominami, K. Georgopoulos, S. Sakaguchi
This study shows that Ikzf1 associates with Foxp3 to repress genes in Treg cells, and disrupting this association leads to autoimmunity and enhanced tumor immunity.
bioRxiv · Aug 12, 2023 · PreprintImmunology