M. Clark

Forecasting the adoption and spread of a community-based marine management initiative using agent-based models

This paper uses agent-based models and Bayesian inference to forecast the adoption and spread of a marine management initiative in Fiji, identifying key drivers and informing conservation policy.

Regional Variations in Live Proportions of Southwest Pacific Cold-Water Coral Solenosmilia variabilis Reefs

The paper quantifies live coral proportions in cold-water coral reefs across different depths and sites, finding depth and aragonite saturation horizon influence live:reef ratios.

Walking (and talking) the plank: Dual-task performance costs in a virtual balance-threatening environment

This study examines dual-task performance costs of walking and speaking in virtual environments with varying anxiety levels, finding that virtual height increases anxiety but not speech pauses.

Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

This study shows that inducing an oxidized redox balance in CD8+ T cells enhances their anti-tumor function in vivo through increased mitochondrial ROS.

BRWD1 orchestrates chromatin topology by converting static to dynamic cohesin complexes

The paper shows BRWD1 converts static to dynamic cohesin complexes in pre-B cells, enabling chromatin topology changes needed for cell fate transitions.

Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor

This study shows dexamethasone enhances CAR T cell persistence and function by upregulating IL7R, improving anti-tumor efficacy in vivo.

Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.

This study shows that loss of obscurin and Obsl1 in mice causes diastolic dysfunction, altered metabolism, and deregulated mitophagy in the heart.

Interspecies Killing Activity of Pseudomonas syringae Tailocins

The paper demonstrates that Pseudomonas syringae strain USA011R produces tailocins with broad interspecies killing activity against phytopathogens and a human pathogen, showing divergence in activity across related strains.

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

Breakpoint models shown no evidence of thresholds in recreational response to increasing wildfire smoke in the American West

The paper analyzes recreational visitation in U.S. national parks in relation to wildfire smoke levels, finding no evidence of a threshold effect on visitor behavior.

Transcriptional profiles of a foliar fungal endophyte (Pestalotiopsis, Ascomycota) and its endohyphal bacterium (Luteibacter, Gammaproteobacteria) in co-culture support sulfur exchange and growth regulation

This study uses dual RNA-seq to compare gene expression of a foliar fungal endophyte and its endohyphal bacterium in co-culture and axenic conditions, revealing sulfur exchange and potential role of type VI secretion system in symbiosis.

Analysis of wild plant pathogen populations reveals a signal of adaptation in genes evolving for survival in agriculture in the beet rust pathogen (Uromyces beticola)

The paper compares genetic diversity in wild and agricultural populations of the beet rust pathogen to identify genes adapting to agriculture, finding greater divergence in fungal effector genes.

Genomic Background Governs Opposing Responses to Nalidixic Acid Upon Megaplasmid Acquisition in Pseudomonas

The paper shows that acquiring a megaplasmid can either sensitize or increase resistance to nalidixic acid in different Pseudomonas strains, depending on their genomic background.

Prophylactic Application of Tailocins Prevents Infection by Pseudomonas syringae

This study shows that tailocins can prevent Pseudomonas syringae infection in Nicotiana benthamiana by targeting specific strains and demonstrates that heritable resistance mutations do not explain tailocin failure.

A single dose of ChAdOx1 MERS provides broad protective immunity against a variety of MERS-CoV strains

A single dose of ChAdOx1 MERS vaccine protects rhesus macaques and mice against MERS-CoV infection and multiple strains.

Substrate-mediated regulation of the arginine transporter of Toxoplasma gondii

This study shows that Toxoplasma gondii regulates its arginine transporter TgApiAT1 expression in response to arginine availability, mediated by a uORF in the transcript.

Identifying transposon insertions in bacterial genomes through nanopore sequencing

The paper evaluates using nanopore sequencing and CRISPR-Cas to identify transposon insertions in bacterial genomes, showing their effectiveness for forward genetic screens.

Experimental Evolution of the Megaplasmid pMPPla107 in Pseudomonas stutzeri Enables Identification of Genes Contributing to Sensitivity to an Inhibitory Agent

The paper uses experimental evolution to identify compensatory mutations in a plasmid that reduce sensitivity to an inhibitory agent in Pseudomonas stutzeri.

A Moving Target: The Megaplasmid pMPPla107 Sensitizes Cells to an Inhibitory Agent Conserved Across Pseudomonas spp.

The paper shows that acquiring the megaplasmid pMPPla107 makes P. syringae strains more sensitive to an inhibitory agent produced by other Pseudomonas species.

Localized Recombination Drives Diversification of Killing Spectra for Phage Derived Syringacins

The paper surveys bacteriocin killing activity across Pseudomonas syringae strains, showing diversity and classification into killing and sensitivity types, with recombination driving activity switches.