BCAT1 inhibition affects CD8+ T cell activation, exhaustion, and tumoral immunity by altering iron homeostasis
F. Lodi, M. Certo, H. Elkafrawy, W. Li, H. A. Vu, K. Gilbo, L. Su, I. L. Pegg, T. Weiss, M. Bühler, M. Weller, C. Yeh, J. E. Corn, K.-S. E. Park, J.-H. Ko, , A. E. Papathanassiu
This study shows BCAT1 inhibition alters iron homeostasis, affecting CD8+ T cell activation, exhaustion, and tumor immunity, with potential as a cancer therapy.
bioRxiv · Feb 25, 2023 · PreprintImmunology