BiophysicsbioRxiv
Transient Thresholding: A Mechanism Enabling Non-Cooperative Transcriptional Circuitry To Form A Switch
K. H. Aull, E. Tanner, M. Thomson, L. S. Weinberger
The paper identifies a transient activation threshold in the HIV Tat circuit that enables temporary latency despite lacking cooperativity and deterministic bistability.
DOI 10.1016/j.bpj.2017.05.002