B. Becher

Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance

This study identifies early yolk sac-derived macrophages in the pituitary gland and shows their role in hormonal regulation and post-pubertal gene expression.

Regulatory T cells control type 1-driven immunopathology restraining GM-CSF-producing helper T cells

This study identifies GM-CSF-producing helper T cells as drivers of immunopathology, showing Treg cells restrain them to prevent tissue damage in mice.

GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to Aspergillus fumigatus

This study identifies GM-CSF produced by SPC+ epithelial cells as critical for neutrophil-mediated immunity against Aspergillus fumigatus, enhancing fungal killing and host survival.

Cell-binding IgM in CSF is distinctive of multiple sclerosis and targets the iron transporter SCARA5

The paper identifies cell-binding IgM in CSF that targets SCARA5 in multiple sclerosis, linking it to complement activation and T cell infiltration.

Epidermal barrier dysregulation in atopic skin predisposes for excessive growth of the allergy-associated yeast Malassezia

This study shows that impaired skin barriers in atopic dermatitis allow Malassezia yeast to grow more efficiently due to changes in the skin's lipid environment.

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

This study identifies a Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis that protects against intestinal inflammation by maintaining barrier integrity and preventing mortality from C. rodentium infection.

Neuroprotective tissue adaptation induced by IL-12 attenuates CNS inflammation

The paper identifies IL-12-responsive neuroectoderm cells that mediate neuroprotection in CNS inflammation, with parallels observed in human MS.

GM-CSF drives immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12

The paper identifies GM-CSF-producing T cells that drive glomerulonephritis by licensing monocyte-derived cells to produce MMP12, leading to renal tissue damage.

CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration following radiation-induced injury

This study identifies CSF1R-dependent macrophages as critical for epithelial regeneration after radiation-induced salivary gland injury.

Single-cell RNA sequencing unveils intestinal eosinophil development and specialization

The paper uses single-cell transcriptomics and flow cytometry to identify five eosinophil subsets in mice, revealing their developmental stages and specialized functions in the GI tract.

Alveolar macrophages strictly rely on GM-CSF from alveolar epithelial type 2 cells before and after birth

This study identifies that alveolar epithelial type 2 cells provide essential GM-CSF for alveolar macrophage development and maintenance before and after birth.

Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis

This study identifies the non-redundant roles of conventional NK cells and tissue-resident ILC1s in controlling liver metastasis through distinct functions in seeding and outgrowth.

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

This study identifies CD39+PD-1+CD8+ T cells as critical for metastatic dormancy in breast cancer, showing their role in suppressing tumor growth and their potential as a biomarker and immunotherapy target.