Author

K. Helmsauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. G. Henssen· 4 shared A. Eggert· 3 shared J. H. Schulte· 3 shared K. Haase· 3 shared R. Chamorro Gonzalez· 3 shared E. Rodriguez-Fos· 2 shared F. Hertwig· 2 shared H. Dorado Garcia· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

A. G. Henssen

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4 papers

Recent·Most cited

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy

L. Grunewald, L. Andersch, K. Helmsauer, S. Schwiebert, A. Klaus, A. G. Henssen, T. Straka, M. Lodrini, S. G. Wicha, S. Fuchs, F. Hertwig, F. Westermann, A. Vitali, C. Caramel, G. Buechel, , A. Kuenkele

This paper shows that high MYCN levels in neuroblastoma reduce L1CAM expression, limiting CAR T cell efficacy, and that inhibiting MYCN with MLN8237 restores L1CAM and enhances CAR T cell activity.

bioRxiv · Jan 27, 2024Immunology

Decoil: Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data

M. Giurgiu, N. Wittstruck, E. Rodriguez-Fos, R. Chamorro Gonzalez, L. Bruckner, A. Krienelke-Szymansky, K. Helmsauer, A. Hartebrodt, R. P. Koche, K. Haase, K. Reinert, A. G. Henssen

Decoil reconstructs complex extrachromosomal DNA structures from long-read sequencing data, improving resolution of ecDNA topology and heterogeneity in cancer.

bioRxiv · Nov 15, 2023Cancer Biology

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy

H. Dorado Garcia, Y. Bei, J. von Stebut, G. Ibanez, K. Imami, D. Gurgen, J. Rolff, K. Helmsauer, N. Timme, V. Bardinet, R. Chamorro Gonzalez, I. C. MacArthur, F. F. Pusch, C. Y. Chen, J. Schulz, , A. G. Henssen

This study identifies ATR as a synthetic lethal target in PAX3-FOXO1-driven rhabdomyosarcoma, showing ATR inhibition enhances PARP inhibitor efficacy and is tolerated in patients.

bioRxiv · Dec 4, 2020 · PreprintCancer Biology

Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma

K. Helmsauer, M. Valieva, S. Ali, R. Chamorro Gonzalez, R. Schoepflin, C. Roeefzaad, Y. Bei, H. Dorado Garcia, E. Rodriguez-Fos, M. Puiggros, V. Heinrich, M. Robson, K. Kasack, K. Haase, L. P. Kuschel, , R. P. Koche

The paper identifies two distinct MYCN amplicon structures in neuroblastoma, showing how enhancer hijacking compensates for loss of local regulatory elements.

bioRxiv · Dec 20, 2019Cancer Biology