J. Rolff

The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is severely constrained by random peptide mixtures

This study shows that random antimicrobial peptide mixtures reduce resistance evolution in Pseudomonas aeruginosa compared to single peptides, preventing cross-resistance and maintaining drug sensitivity.

Rapid growth and the evolution of complete metamorphosis in insects

This study investigates why holometabolous insects evolved a pupal stage, finding that rapid growth and a trade-off between growth and differentiation favor this life history under high mortality.

How frequently are insects wounded in the wild? A case study using Drosophila melanogaster

This study investigates the prevalence and causes of wounding in wild Drosophila melanogaster, finding that 31% of individuals were wounded, with females more frequently injured on the ventral abdomen.

Antimicrobial activity of cationic antimicrobial peptides against stationary phase bacteria

This study shows that five antimicrobial peptides effectively kill non-dividing E. coli and S. aureus, unlike conventional antibiotics, suggesting AMPs could be promising for drug development.

IMMUNE GENE REGULATION IN THE GUT DURING METAMORPHOSIS IN TWO HOLO- VERSUS A HEMIMETABOLOUS INSECT

This study compares immune gene expression in the gut during metamorphosis in holometabolous and hemimetabolous insects, finding that only holometabolous insects show high immune effector expression during larval-pupal moult.

Complete metamorphosis and microbiota turnover in insects

This study compares microbiota turnover between holometabolous and hemimetabolous insects, finding higher beta-diversity in holometabolous species due to pupation-induced gut microbiota replacement.

Bistable host-pathogen interaction explains varied infection outcomes

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy

This study identifies ATR as a synthetic lethal target in PAX3-FOXO1-driven rhabdomyosarcoma, showing ATR inhibition enhances PARP inhibitor efficacy and is tolerated in patients.

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics and treatment regimens

The paper investigates how drug resistance evolves through single or multiple mutations and shows that treatment strategies affect resistance development and population diversity.

Antimicrobial peptide induced-stress renders Staphylococcus aureus susceptible to toxic nucleoside analogues

The paper shows that sub-lethal concentrations of the antimicrobial peptide pexiganan increase susceptibility of Staphylococcus aureus to nucleoside analogues.

Bacteria primed by antimicrobial peptides develop tolerance and persist

This study shows that prior exposure to sublethal doses of antimicrobial peptides increases bacterial survival and promotes resistance evolution in E. coli through mechanisms like curli or colanic acid production.

Non-lethal exposure to H2O2 boosts bacterial survival and evolvability against oxidative stress

This study shows that non-lethal H2O2 exposure primes bacterial survival and accelerates evolution of resistance to oxidative stress.

A constitutively expressed antifungal peptide protects Tenebrio molitor during a natural infection by the entomopathogenic fungus Beauveria bassiana.

This study examines the role of Tenecin 3, a constitutively expressed antifungal peptide in Tenebrio molitor, during infection by Beauveria bassiana, showing its protective effect on host survival and fungal progression.

Predicting drug resistance evolution: insights from antimicrobial peptides and antibiotics

The paper predicts that resistance evolution is less likely against antimicrobial peptides compared to antibiotics due to their pharmacodynamic differences, offering a framework for antibiotic stewardship.