S. Fuchs

Helicobacter pylori gamma-glutamyltransferase relates to proteomic adaptions important for gastric colonization

This study investigates the role of Helicobacter pylori gamma-glutamyltransferase (gGT) in gastric colonization and identifies compensatory mechanisms when gGT is absent.

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy

This paper shows that high MYCN levels in neuroblastoma reduce L1CAM expression, limiting CAR T cell efficacy, and that inhibiting MYCN with MLN8237 restores L1CAM and enhances CAR T cell activity.

Conformational dynamics and target-dependent myristoyl switch of calcineurin B homologous protein 3

This study investigates the conformational dynamics and target-dependent myristoyl switch of CHP3, revealing that Ca2+ binding and myristoylation independently regulate its function and membrane association.

Hybrid conferences: opportunities, challenges and ways forward

The paper reports on organizing a hybrid conference, identifies challenges, and suggests improvements to enhance accessibility and inclusivity.

Listeria monocytogenes gene essentiality under laboratory conditions and during macrophage infection

This study identifies essential genes for Listeria monocytogenes growth in laboratory conditions and during macrophage infection using Tn-Seq.

Fusing spheroids to aligned μ-tissues in a Heart-on-Chip featuring oxygen sensing and electrical pacing capabilities

This paper introduces a Heart-on-Chip system using spheroids to generate aligned cardiac tissues with electrical pacing and oxygen sensing capabilities.

The lifetime cost of reproductive potential, who spends the most?

The paper compares lifetime energy investment in gamete maintenance between men and women, finding men invest 300-fold more energy than women.

Critical Assessment of Metaproteome Investigation (CAMPI): a Multi-Lab Comparison of Established Workflows

CAMPI evaluates metaproteomic workflows across labs, finding sample processing drives peptide variability while workflows yield similar functional profiles.

Anopheles coluzzii stearoyl-CoA desaturase is essential for adult female survival and reproduction upon blood feeding

This study shows that SCD1 is critical for Anopheles coluzzii female survival and reproduction after blood feeding, as its disruption leads to metabolic dysregulation and immune activation.