Author

K. Jack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:metagenomics· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Sangar· 2 shared J. Bieschke· 2 shared A. Solomon· 1 shared B. Mistry· 1 shared C. h. Roberts· 1 shared C. Palmer· 1 shared C. Russell· 1 shared D. Mabey· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

D. Sangar

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Syntaxin 6 delays prion protein fibril formation and prolongs presence of toxic aggregation intermediates

D. Sangar, E. Hill, K. Jack, M. Batchelor, B. Mistry, J. M. Ribes, G. S. Jackson, S. Mead, J. Bieschke

This study shows syntaxin-6 inhibits PrP fibril formation but prolongs toxic intermediate aggregates, suggesting it acts as an anti-chaperone in prion disease.

bioRxiv · Aug 25, 2022Biochemistry

Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics

Y. Sun, K. Jack, T. Ercolani, D. Sangar, L. L. Hosszu, J. Collinge, J. Bieschke

This study uses super-resolution microscopy to observe competing prion protein fibril populations with distinct structures and kinetics, revealing their quasi-species behavior.

bioRxiv · Aug 10, 2022Biophysics

Active Trachoma Cases In The Solomon Islands Have Varied Polymicrobial Community Structures But Do Not Associate With Individual Non-Chlamydial Pathogens Of The Eye

R. Butcher, O. Sokana, K. Jack, E. Kalae, L. Sui, C. Russell, J. Houghton, C. Palmer, M. J. Holland, R. Le Mesurier, A. Solomon, D. Mabey, C. h. Roberts

The paper investigates whether active trachoma in the Solomon Islands is linked to non-chlamydial pathogens or polymicrobial dysbiosis, finding no significant association with individual pathogens but noting inter-individual microbiome variation.

bioRxiv · Oct 10, 2017Microbiology