Author

K. Koussis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

M. J. Blackman· 3 shared A. P. Snijders· 2 shared C. Withers-Martinez· 2 shared D. A. Baker· 2 shared H. R. Flynn· 2 shared S. A. Howell· 2 shared A. C. Balestra· 1 shared A. Hainard· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

M. J. Blackman

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Author profile →

3 papers

Recent·Most cited

Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.

K. Koussis, S. Haase, C. Withers-Martinez, H. R. Flynn, S. Kunzelmann, E. Christodoulou, F. Ibrahim, M. Skehel, D. A. Baker, M. J. Blackman

This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.

bioRxiv · Feb 4, 2024Microbiology

A malaria parasite phospholipase facilitates efficient asexual blood stage egress

A. Ramaprasad, P.-C. Burda, K. Koussis, J. A. Thomas, E. Pietsch, E. Calvani, S. A. Howell, J. I. MacRae, A. P. Snijders, T. W. Gilberger, M. J. Blackman

This study identifies LCAT as a key enzyme required for efficient egress of malaria parasites from red blood cells during the asexual blood stage.

bioRxiv · Mar 13, 2023Microbiology

A multipass membrane protein interacts with the cGMP-dependent protein kinase to regulate critical calcium signals in malaria parasites

A. C. Balestra, K. Koussis, N. Klages, S. A. Howell, H. R. Flynn, M. Bantscheff, C. Pasquarello, A. J. Perrin, L. Brusini, P. Arboit, O. Sanz, L. Peces-Barba Castano, C. Withers-Martinez, A. Hainard, S. Ghidelli-Disse, , M. Brochet

This study identifies ICM1, a multipass membrane protein interacting with PKG in malaria parasites, and shows it regulates calcium signals critical for gametogenesis and parasite survival.

bioRxiv · Jul 18, 2020Microbiology