M. Brochet

Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation

This study identifies NEK1's role in organizing the MTOC and ensuring kinetochore attachment during rapid mitosis in Plasmodium male gamete formation.

A multistage Plasmodium CRL4-WIG1 ubiquitin ligase is critical for the formation of functional microtubule organisation centres in microgametocytes

This study identifies a CRL4-related ubiquitin ligase in Plasmodium that is critical for microgametocyte formation by regulating proteostasis of ciliary and DNA replication proteins.

Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation, and chromosome segregation of sexual transmission stages

An Sfi1-like centrin-interacting centriolar plaque protein affects nuclear microtubule homeostasis.

The paper identifies a novel centrin-interacting centriolar plaque protein in Plasmodium falciparum and shows its role in regulating nuclear microtubule homeostasis.

Conoid extrusion serves as gatekeeper for entry of glideosome components into the pellicular space to control motility and invasion in Apicomplexa

The paper identifies new components of the conoid in Apicomplexa and shows it regulates glideosome assembly and motility by controlling F-actin flux.

Organization and composition of apicomplexan kinetochores reveals plasticity in chromosome segregation across parasite modes of division

This study identifies novel kinetochore components in apicomplexan parasites and reveals plasticity in kinetochore composition and chromosome segregation across their lifecycle.

Ultrastructure expansion microscopy of Plasmodium gametocytes reveals the molecular architecture of a microtubule organisation centre coordinating mitosis with axoneme assembly

This study uses ultrastructure expansion microscopy to reveal the molecular architecture of a bipartite MTOC in Plasmodium gametocytes that coordinates mitosis with axoneme assembly.

Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle

The paper identifies key kinesins involved in the malaria parasite life cycle in mammalian and mosquito hosts, showing kinesin-13 is essential for growth in mammals while others are critical for mosquito transmission.

Protein Phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages

The paper investigates the role of Protein Phosphatase 1 (PP1) in atypical mitotic and meiotic divisions during Plasmodium sexual stages, suggesting PP1 inhibitors could block parasite transmission.

A multipass membrane protein interacts with the cGMP-dependent protein kinase to regulate critical calcium signals in malaria parasites

This study identifies ICM1, a multipass membrane protein interacting with PKG in malaria parasites, and shows it regulates calcium signals critical for gametogenesis and parasite survival.

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of Plasmodium berghei during gametogony and parasite transmission.

This study identifies CRK5 as a critical regulator of atypical DNA replication in Plasmodium berghei during gametogony and mosquito transmission.

Sub-minute phosphoregulation of cell-cycle systems during Plasmodium gamete formation

This study identifies phosphoregulation networks during Plasmodium gamete formation using high-resolution phosphoproteomics.