D. A. Baker

Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.

This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.

Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but not linked to sexual commitment

Variation in Plasmodium falciparum sexual commitment rates and responses to environmental modification

This study measures sexual commitment rates in Plasmodium falciparum using two methods, finds higher sensitivity with an early marker, and reports variation across isolates and lab lines.

Limited within-host diversity and tight transmission bottlenecks limit SARS-CoV-2 evolution in acutely infected individuals

The paper analyzes SARS-CoV-2 within-host diversity and transmission bottlenecks in acute infections, finding limited diversity and narrow bottlenecks that restrict variant spread.

Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck

This study shows SARS-CoV-2 in cats has limited within-host genetic variation and a narrow transmission bottleneck, with a variant H655Y emerging and spreading across transmission pairs.

The landscape of antibody binding in SARS-CoV-2 infection

This study identifies B cell epitopes across the SARS-CoV-2 proteome using peptide microarrays, showing antibody reactivity to multiple viral proteins and correlations with illness severity.

A multipass membrane protein interacts with the cGMP-dependent protein kinase to regulate critical calcium signals in malaria parasites

This study identifies ICM1, a multipass membrane protein interacting with PKG in malaria parasites, and shows it regulates calcium signals critical for gametogenesis and parasite survival.

Use of a highly specific kinase inhibitor for rapid, simple and precise synchronization of Plasmodium falciparum and Plasmodium knowlesi asexual stage parasites

High-throughput identification of MHC class I binding peptides using an ultradense peptide array

This paper uses an ultradense peptide array to identify MHC class I binding peptides, finding 64% of known epitopes and three novel ones in rhesus macaques.

MHC genotyping from rhesus macaque exome sequences

This study introduces a method to genotype MHC class I and II from rhesus macaque exome sequences with high accuracy, outperforming conventional methods.

Modification of an atypical clathrin-independent AP-2 adaptin complex of Plasmodium falciparum reduces susceptibility to artemisinin

This study shows that modifying the AP-2 adaptin complex in Plasmodium falciparum reduces susceptibility to artemisinin, suggesting alternative mechanisms of drug resistance beyond pfkelch13 mutations.

Rapid and iterative genome editing in the zoonotic malaria parasite Plasmodium knowlesi: New tools for P. vivax research

This study develops CRISPR-Cas9 genome editing in Plasmodium knowlesi to generate a transgenic line expressing P. vivax Duffy binding protein, showing its role in host cell tropism and vaccine potential.

Subclinical infection of macaques and baboons with a baboon simartevirus

This study infects olive baboons and rhesus macaques with SWBV-1, a simartevirus, and finds no disease in either species despite high viral replication and immune responses.

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

The paper integrates omics data to identify gametocyte-specific genes and transcripts in malaria parasites, finding novel biomarkers and validating their expression in natural infections.