Pharmacology & ToxicologybioRxivPreprint
ncBAF, a chromatin remodeler, enhances PXR-mediated transcriptional activation in the human and mouse liver
K. Kurosawa, M. Nakano, I. Yokoseki…·M. Nakajima
This study shows that inhibiting BRD9, a component of ncBAF, reduces PXR-mediated transcriptional activation and associated adverse effects in liver cells and mice.