Pharmacology & ToxicologybioRxivPreprint
Elexacaftor/Tezacaftor/Ivacaftor alters branching morphogenesis of the mouse embryonic lung
M. Lhuillier, L. Aoust, E. Dreano…·A. Hadchouel Duverge
This paper shows that the triple CFTR modulator therapy ETI reduces lung branching and increases terminal bud dilation in mouse embryos, suggesting potential developmental risks.
DOI 10.1101/2021.11.01.466814