Streamlined screening platforms lead to the discovery of pachysiphine synthase from Tabernanthe iboga
M. O. Kamileen, Y. Nakamura, K. Luck, S. Heinicke, B. Hong, M. Colinas, B. R. Lichman, S. E. O'Connor
The paper identifies two CYP450 enzymes in Tabernanthe iboga responsible for oxidative modifications of tabersonine scaffolds using a streamlined screening strategy in Nicotiana benthamiana.
bioRxiv · Jun 30, 2024 · PreprintBiochemistry