Author

H. Lyu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:experimental assay· 7 Research Focus:differential expression· 5 Organism:human· 5 Assay:proteomics· 5 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

A. A. Saei· 4 shared R. A. Zubarev· 4 shared A. Vegvari· 3 shared H. Gharibi· 3 shared M. Gaetani· 3 shared S. L. Lundstrom· 2 shared S. P. Gygi· 2 shared W. Lu· 2 shared

Activity by Year

2022-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersBiochemistry

A. A. Saei

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Phenylphenalenones and Linear Diarylheptanoid Derivatives are Biosynthesized via Parallel Routes in Musella lasiocarpa, the Chinese Dwarf Banana

H. Lyu, L. Ernst, Y. Nakamura, Y. Okamura, T. Koellner, K. Luck, B. Liu, Y. Chen, L. Beerhues, J. Gershenzon, C. Paetz

The paper identifies biosynthetic genes and pathways for phenylphenalenones and linear diarylheptanoid derivatives in Musella lasiocarpa using transcriptomics and biochemical assays.

bioRxiv · Mar 11, 2024 · PreprintBiochemistry

Gel-Assisted Proteome Position Integral Shift (GAPPIS) Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Novel Caspase 3 Substrates

Z. Meng, A. A. Saei, X. Zhang, H. Lyu, H. Gharibi, S. L. Lundstrom, A. Vegvari, M. Gaetani, R. A. Zubarev

The paper introduces GAPPIS, a method to recover molecular weight information from shotgun proteomics, identifying novel caspase 3 substrates in apoptotic cells.

bioRxiv · Feb 14, 2024 · PreprintBiochemistry

Coordinated Immune Cell Networks in the Bone Marrow Microenvironment Define the Graft versus Leukemia Response with Adoptive Cellular Therapy

K. Maurer, C. Park, S. Mani, M. Borji, L. Penter, Y. Jin, J. Y. Zhang, C. Shin, J. R. Brenner, J. Southard, S. Krishna, W. Lu, H. Lyu, D. Abbondanza, C. Mangum, , E. Azizi

The paper analyzes single-cell data from bone marrow samples to identify immune cell interactions that predict response to adoptive cellular therapy in myeloid leukemia.

bioRxiv · Feb 9, 2024 · PreprintCancer Biology

Chemical proteomics reveals that the anticancer drug everolimus affects ubiquitin-proteasome system

A. A. Lobas, A. A. Saei, H. Lyu, R. A. Zubarev, M. V. Gorshkov

This study shows that everolimus, a rapamycin analog, uniquely affects the ubiquitin-proteasome system by increasing ubiquitin levels and altering polyubiquitination patterns, distinct from its analogs.

bioRxiv · Oct 15, 2023Cancer Biology

Multifaceted proteome analysis at solubility, redox, and expression dimensions for target identification

A. A. Saei, A. Lundin, H. Lyu, H. Gharibi, H. Luo, J. Teppo, X. Zhang, M. Gaetani, A. Vegvari, R. Holmdahl, S. P. Gygi, R. A. Zubarev

The paper introduces PISA-REX, a high-throughput proteomics method combining redox, expression, and solubility analysis, and demonstrates its application in studying interferon responses in human monocytes and mice.

bioRxiv · Aug 31, 2023Biochemistry

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

H. Lyu, G. Yuan, X. Liu, X. Wang, S. Geng, T. Xia, X. Zhou, Y. Li, X. Hu, Y. Shi

This study shows that sustained store-operated calcium entry (SOCE) and chromatin accessibility in iTregs lead to phenotypical instability, unlike tTregs.

bioRxiv · Jun 4, 2023Immunology

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

K. K. Mahadevan, K. McAndrews, V. LeBleu, S. Yang, H. Lyu, B. Li, A. M. Sockwell, M. L. Kirtley, S. J. Morse, B. M. Moreno Diaz, M. P. Kim, N. Feng, A. M. Lopez, P. A. Guerrero, H. Sugimoto, , R. Kalluri

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

bioRxiv · Feb 15, 2023 · PreprintCancer Biology

Mapping the GALNT1 substrate landscape with versatile proteomics tools

A. A. Saei, S. L. Lundstrom, H. Lyu, H. Gharibi, W. Lu, P. Fang, X. Zhang, Z. Meng, J. Wang, M. Gaetani, A. Vegvari, S. P. Gygi, R. A. Zubarev

This study identifies hundreds of novel GALNT1 substrates using proteomics tools, revealing preferences for Thr residues and Pro at positions +3 and +4, and implicating GALNT1 in diverse biological pathways.

bioRxiv · Aug 24, 2022 · PreprintBiochemistry