Animal Behavior & CognitionbioRxiv
Behavioral dysregulation and monoaminergic deficits precede memory impairments in human tau-overexpressing (htau) mice
K. M. Khan, G. P. Selvakumar, N. Balasubramanian…·C. A. Marcinkiewcz
This study shows that depressive-like behaviors and monoaminergic deficits occur before memory impairments in htau mice, suggesting early tau pathology impacts serotonergic neurons.
DOI 10.1186/s40478-023-01546-5