Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
A. L. B. Pyne, A. Noy, K. Main, V. Velasco-Berrelleza, M. M. Piperakis, L. A. Mitchenhall, F. M. Cugliandolo, J. G. Beton, C. E. M. Stevenson, B. W. Hoogenboom, A. D. Bates, A. Maxwell, S. A. Harris
This study uses AFM and MD simulations to analyze how DNA supercoiling affects structure and triplex-forming oligonucleotide binding at base-pair resolution.
bioRxiv · Jan 7, 2021Biophysics