W. Xia

ALS-causing SOD1 mutations H46R and G85R form similar novel amyloid fibril structures and promote ferroptosis in cells

This study shows that two ALS-causing SOD1 mutations form similar amyloid fibrils that promote ferroptosis in neuronal cells.

Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses

The paper identifies hexa-acylated lipopolysaccharides from the gut microbiome as a biomarker and enhancer of anti-PD-1 immunotherapy responses in melanoma patients.

ApoE ε4-dependent alteration of CXCR3+CD127+ CD4+ T cells is associated with elevated plasma neurofilament light chain in Alzheimer's disease

The paper finds that ApoE ε4-dependent changes in CXCR3+CD127+ CD4+ T cells in peripheral blood correlate with elevated neurofilament light chain in Alzheimer's disease.

Nuclear cytoophidia assembly represses transcriptional activity to control skeletal development and homeostasis

This study identifies nuclear cytoophidia as regulators of Impdh2 transcriptional activity, impacting skeletal development and homeostasis through effects on endochondral ossification and osteoclast function.

Enterocloster clostridioformis induces host intestinal epithelial responses that protect against Salmonella infection

The paper identifies Enterocloster clostridioformis as a protective commensal bacterium that induces host intestinal epithelial responses to resist Salmonella infection.

Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures

This study shows that phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures with different neurotoxicity and propagation properties.

Language gene polymorphism pattern survey provided important information for education context in human evolution

The study analyzes language gene polymorphism patterns across populations to infer human evolutionary history and finds that ancient samples from Nepal contain all four distinct LGPPs.

Adipocyte-secreted IL-6 sensitizes macrophages to IL-4 signaling

The paper shows that adipocyte-secreted IL-6 enhances macrophage sensitivity to IL-4 signaling through STAT3 activation and Il4ra expression.

Trophoblast and blood vessel organoid cultures recapitulate the role of WNT2B in promoting intravillous vascularization in human intrauterine and ectopic pregnancy

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

Different structures and pathologies of alpha-synuclein fibrils derived from preclinical and postmortem patients of Parkinson's disease

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

A Potential Novel COVID-19 Vaccine With RBD-HR1/HR2 Hexamer Structure

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes

Exploring the natural origins of SARS-CoV-2 in the light of recombination

This paper traces the origins of SARS-CoV-2 to horseshoe bats in China and Southeast Asia, identifies recombination events in Sarbecoviruses, and highlights the need for more wildlife sampling to understand zoonotic spillover risks.

Environmental conditions and diffusion-limited microbial transfer drive specific microbial communities detected at different sections in oil-production reservoir with water-flooding

This study examines microbial community distribution in oil-production reservoirs, finding that environmental variation and diffusion-limited transfer shape distinct communities in different sections.

A Novel SARS-CoV-2 Multitope Protein/Peptide Vaccine Candidate is Highly Immunogenic and Prevents Lung Infection in an AAV hACE2 Mouse Model and non-human primates

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

This study reveals that the nuclear localization sequence of hnRNPA1 forms the core of amyloid fibrils and interacts with Kap{beta}2 to stabilize them, linking nucleo-cytoplasmic transport to neurodegeneration.

The dominance hierarchy of the female Yunnan snub-nosed monkeys (Rhinopithecus bieti)

The study examines dominance hierarchies among female Yunnan snub-nosed monkeys using aggressive-submissive behaviors and grooming reciprocity, finding loose hierarchies and higher grooming income for dominant individuals.

Proteomic and Biological Profiling of Extracellular Vesicles from Alzheimer’s Disease Human Brain Tissues

The paper profiles proteomic and biological features of extracellular vesicles from Alzheimer’s disease and control brain tissues, identifying new signature proteins associated with AD.

A Single-Cell Immune Atlas of Triple Negative Breast Cancer Reveals Novel Immune Cell Subsets

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

Clinical Significance of C4d Deposition in Renal Tissues from Patients with Primary Sj&oumlgren's Syndrome--A Preliminary Study

This study examines C4d deposition in renal tissues of primary Sjögren's syndrome patients, finding higher serum creatinine levels in those with tubulointerstitial C4d positivity.

Polymerization Kinetics Stability, Volumetric Changes, Apatite Precipitation, Strontium Release and Fatigue of Novel Bone Composites for Vertebroplasty

This study evaluates the effects of diluent monomers and MCPM on the polymerization kinetics, volumetric stability, apatite precipitation, strontium release, and fatigue properties of novel bone composites for vertebroplasty.

Persistence of Resident and Transplanted Genotypes of the Undomesticated Yeast, Saccharomyces paradoxus in Forest Soil

This study shows that Saccharomyces paradoxus and S. cerevisiae persist in forest soil over years, with abundance fluctuating with rainfall and drought.