A. Noy

The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states

This study investigates the conformational transitions of Rep helicase using single-molecule techniques, revealing two intermediate states influenced by salt concentration.

Evaluation in mice of cell-free produced CT584 as a Chlamydia vaccine antigen

This study evaluates CT584, a Chlamydia antigen produced via cell-free synthesis, as a vaccine in mice, finding it induces antibodies but not protection against infection.

Correlating fluorescence microscopy, optical and magnetic tweezers to study single chiral biopolymers such as DNA

The paper introduces COMBI-Tweez, a tool combining optical and magnetic tweezers with fluorescence microscopy to study the structural dynamics of single chiral biopolymers like DNA under mechanical forces.

Atomic description of the reciprocal action between supercoils and melting bubbles on linear DNA

The paper uses molecular dynamics simulations to study DNA supercoiling and melting bubbles, revealing a new state in negative supercoiling where denaturation bubbles form in AT-rich regions.

Structural interplay between DNA-shape proteinrecognition and supercoiling: the case of IHF

This study reveals how IHF interacts with supercoiled DNA through molecular dynamics simulations, showing IHF's role in modulating superhelical stress and organizing DNA topology.

Rolling Circle RNA Synthesis Catalysed by RNA

This study demonstrates RNA-catalysed rolling circle synthesis on circular RNAs, showing strand displacement and concatemeric product formation, suggesting RNA can support complex replication pathways.

Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides

This study uses AFM and MD simulations to analyze how DNA supercoiling affects structure and triplex-forming oligonucleotide binding at base-pair resolution.

Diversification of DNA-binding specificity via permissive and specificity-switching mutations in the ParB/Noc protein family

This study investigates how DNA-binding specificity diversifies in ParB and Noc proteins by identifying key residues and mutational paths that reprogram specificity.

Integration host factor bends and bridges DNA in a multiplicity of binding modes with varying specificity

The paper shows IHF binds DNA in three distinct modes with varying specificity, enabling DNA compaction and structural organization.

SerraNA: a program to determine nucleic acids elasticity from simulation data

SerraNA calculates elastic parameters of nucleic acids from simulation data, revealing sequence-dependent elasticity and global bendability from local bending angles.