Author

K. McLean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Physiology· 2 Evolutionary Biology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Assay:electrophysiology· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Winstanley· 3 shared D. Fernig· 3 shared D. M. Foulkes· 3 shared N. Berry· 3 shared S. B. Kaye· 3 shared A. Haneef· 1 shared A. Hermann· 1 shared A. J. Nisbet· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

C. Winstanley

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Validation of a Demography-Based Adaptive QTc Formula using Pediatric and Adult Datasets Acquired from Humans and Guinea Pigs

K. Haq, K. McLean, G. Anderson-Barker, C. Berul, M. Shattock, N. Posnack

This study introduces and validates an adaptive QTc formula (QTcAd) that adjusts for age demographics, showing improved performance across human and guinea pig age groups compared to existing formulas.

bioRxiv · Jul 10, 2024 · PreprintPhysiology

Electroanatomical Adaptations in the Guinea Pig Heart from Neonatal to Adulthood

K. T. Haq, K. McLean, S. Salameh, L. M. Swift, N. G. Posnack

This study examines electroanatomical changes in guinea pig hearts from neonatal to adult stages, finding age-related differences in conduction velocity, action potential duration, and excitation-contraction coupling.

bioRxiv · Jan 26, 2024Physiology

Characterisation of protective vaccine antigens from the thiol-containing components of excretory/secretory material of Ostertagia ostertagi

D. R. G. Price, P. Steele, D. Frew, K. McLean, D. Androscuk, P. Geldhof, J. Borloo, J. Palarea-Albaladejo, A. J. Nisbet, T. N. McNeilly

The paper identifies and characterizes protective antigens in a vaccine preparation from Ostertagia ostertagi excretory-secretory material using proteomics.

bioRxiv · Dec 8, 2023 · PreprintZoology

A phospholipase assay screen identifies synergistic inhibitors of the P. aeruginosa toxin ExoU

D. M. Foulkes, K. McLean, A. Hermann, J. Johnson, C. Winstanley, N. Berry, D. Fernig, S. B. Kaye

This study identifies synergistic inhibitors of P. aeruginosa ExoU through a phospholipase assay screen, showing reduced cytotoxicity in vitro and in corneal assays.

bioRxiv · Feb 21, 2022 · PreprintBiochemistry

Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity

D. M. Foulkes, K. McLean, M. Sloniecka, D. Byrne, A. S. Haneef, C. Winstanley, N. Berry, D. Fernig, S. B. Kaye

This study evaluates the effects of fluoroquinolones and aminoglycosides on P. aeruginosa T3SS expression and cytotoxicity in corneal epithelial cell models, finding tobramycin inhibits T3SS and cytotoxicity while fluoroquinolones upregulate T3SS and enhance cytotoxicity.

bioRxiv · Oct 11, 2021Biochemistry

Trophic specialization on unique resources in one of the most celebrated examples of sympatric speciation, Barombi Mbo crater lake cichlids

J. Galvez, K. McLean, C. D. Touokong, L. N. Gonwouo, C. Martin

The paper quantitatively analyzes dietary niche partitioning in Barombi Mbo cichlids, finding little trophic niche partitioning but evidence of dietary specialization on rare resources.

bioRxiv · Aug 4, 2021 · PreprintEvolutionary Biology

Evaluation of ExoU inhibitors in a Pseudomonas aeruginosa scratch infection assay

D. M. Foulkes, K. McLean, J. Harris, A. Haneef, D. Fernig, C. Winstanley, N. Berry, S. B. Kaye

This study evaluates ExoU inhibitors in a Pseudomonas aeruginosa scratch infection model, showing their effectiveness in reducing cytotoxicity when combined with antimicrobials.

bioRxiv · Jun 24, 2020 · PreprintBiochemistry