A. Hermann

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

Differential roles of beta-cell IP3R and RyR ER Ca2+ channels in ER stress-induced alterations of beta-cell Ca2+ homeostasis

This study investigates how ER stress affects IP3R and RyR Ca2+ channels in beta cells, showing RyR1 dysfunction contributes to Ca2+ dysregulation and apoptosis.

A phospholipase assay screen identifies synergistic inhibitors of the P. aeruginosa toxin ExoU

This study identifies synergistic inhibitors of P. aeruginosa ExoU through a phospholipase assay screen, showing reduced cytotoxicity in vitro and in corneal assays.

Changes in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithium

This study examines blood cell deformability in Chorea-Acanthocytosis patients and evaluates the effects of dasatinib or lithium treatment on red blood cell and leukocyte mechanics.

Optogenetic manipulation of YAP cellular localisation and function

This paper develops optoYAP, an optogenetic tool to control YAP localization and function, showing it can regulate gene expression, proliferation, and growth in cell culture and zebrafish embryos.

Co-condensation of proteins with single- and double-stranded DNA

This study uses optical tweezers to show FUS protein forms liquid-like co-condensates with DNA by adsorbing on single and double-stranded DNA, revealing phase separation mechanisms in nuclear compartments.

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to most known recently emerging RBD mutations

The paper describes the selection of a SARS-CoV-2 neutralizing antibody from COVID-19 patients using phage display, showing it binds the ACE2-RBD interface and remains effective against emerging RBD mutations.

Correlative all-optical quantification of mass density and mechanics of sub-cellular compartments with fluorescence specificity

This paper introduces FOB microscopy to measure sub-cellular density and mechanics with fluorescence specificity, revealing differences between nucleoplasm and cytoplasm.