K. Miller-Jensen

This study identifies functionally and metabolically distinct melanoma-associated macrophages originating from common bone-marrow precursors, with implications for targeted therapy.

The paper investigates the role of apoptosis recognition receptors in skin wound repair using mouse models and single-cell RNA sequencing, finding that Axl signaling is critical for repair while Timd4 is essential for efferocytosis.

The paper uses single-cell analysis to show IL-10 both restrains and resolves TLR4-induced inflammation by modulating cytokine secretion thresholds and signaling pathways.

This study shows that co-stimulation with opposing macrophage polarization cues leads to cell-to-cell heterogeneity in transcription and secretion programs.