M. Wolkers

SONAR, a machine learning pipeline, learns the sequence code for protein abundance in human immune cells, revealing cell type-specific and activation-dependent sequence features that can enhance T cell receptor expression.

This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.

This study shows that m6A methylation on specific DNA sequences enhances immune recognition by macrophages and dendritic cells through STING-dependent pathways, with sequence-specific immunostimulatory or suppressive effects.

This study identifies CD29 as a marker for cytotoxic CD8+ T cells, showing its stability and utility in enhancing anti-tumoral activity.

This study shows TLR2 ligands lower antigen thresholds for cytokine production and enhance polyfunctional CD8+ T cell responses through mRNA stabilization and costimulation.