Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells
J. Nideffer, M. Ty, M. Donato, J. Rek, R. Kajubi, X. Ji, H. Maecker, F. Nankya, K. Musinguzi, K. Press, B. Greenhouse, M. Kamya, M. E. Feeney, G. Dorsey, P. Utz, , P. Jagannathan
The paper shows that repeated Plasmodium infection leads to epigenetic changes in innate immune cells, which suppress inflammation and confer long-term disease tolerance in Ugandan children.
bioRxiv · Apr 19, 2023 · PreprintImmunology