X. Ji

Substrate specificity and protein stability drive the divergence of plant-specific DNA methyltransferases

This study investigates how CMT2 and CMT3 diverge in substrate specificity and protein stability, revealing evolutionary mechanisms of DNA methylation in plants.

AI-driven high-throughput droplet screening of cell-free gene expression

This paper introduces DropAI, an AI-driven droplet-based screening method to optimize cell-free gene expression systems, achieving cost reduction and yield improvement.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

Decellularized biohybrid nerve promotes motor axon projections

This study develops a biohybrid nerve graft using decellularized rat sciatic nerve modified with PEDOT to promote directed motor axon growth, showing improved conductivity and cell compatibility.

Hosts Manipulate Lifestyle Switch and Pathogenicity Heterogeneity of Opportunistic Pathogens in the Single-cell Resolution

The paper shows how Drosophila larvae influence the lifestyle and pathogenicity of Serratia marcescens at the single-cell level through transcriptomic and metabolic changes.

Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity

The paper presents cryo-EM structures of human SIDT1 and SIDT2, revealing their dimeric architecture and demonstrating low-pH-dependent RNA binding and oligomerization.

Toxicokinetic Characterization of the Inter-Species Differences in 6PPD-Quinone Toxicity Across Seven Fish Species: Metabolite Identification and Semi-Quantification

This study identifies and semi-quantifies 6PPD-Quinone metabolites in fish species to explore inter-species differences in toxicity and detoxification.

A Hybrid Transistor with Transcriptionally Controlled Computation and Plasticity

This paper describes hybrid OECTs with Shewanella oneidensis that translate biological computation into electrical responses using transcriptional control of extracellular electron transfer.

Artemisitene protected against murine schistosomiasis japonica through anti-parasite activity and immune regulation

This paper shows artemisitene reduces Schistosoma japonicum infection and liver damage in mice by killing parasites and modulating immune responses.

Characterization of N-glycosylation and its Functional Role in SIDT1-Mediated RNA Uptake

This study maps N-glycosylation sites in SIDT1 and SIDT2 and shows their role in RNA uptake, cell surface expression, and protein stability.

Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

This paper introduces an electrocatalytic system for on-site oxygen production to support cell therapies under hypoxic conditions.

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

The paper shows that repeated Plasmodium infection leads to epigenetic changes in innate immune cells, which suppress inflammation and confer long-term disease tolerance in Ugandan children.

BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune CheckpointSensitivity in BRAFV600E-mutant Glioma

This study shows that BRAF/MEK inhibition induces cell state transitions in BRAFV600E-mutant gliomas, leading to PD-L1 upregulation and immune evasion, which can be overcome by combining with immune checkpoint inhibition.

Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

This study shows that impaired glucose metabolism in osteoblasts causes reduced bone formation in type 2 diabetic mice, and identifies potential therapeutic targets.

Construction of Model Animals to Explore Intestinal Microbiome for Detection of Breast Cancer

This study investigates the relationship between breast cancer and gut microbiome by analyzing fecal samples from mice with induced breast tumors, finding changes in microbial composition and signaling pathways.

Implications of differential size-scaling of cell-cycle regulators on cell size homeostasis

The paper models how differential scaling of cell-cycle regulators with cell size affects cell division timing and size homeostasis, showing robust growth and division with specific scaling behaviors.

Crystal structure of monkeypox H1 phosphatase, an Antiviral Drug Target

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

Sensitivity of diffusion-tensor and correlated diffusion imaging to white-matter microstructural abnormalities: application in COVID-19

This study compares diffusion MRI methods to detect white-matter changes in COVID-19 patients, finding correlated diffusion imaging is most sensitive to microstructural abnormalities.

Integrated Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of Acute Graft-versus-Host-Disease

This study identifies how regulatory T cells suppress acute graft-versus-host disease by modulating conventional T cell transcriptomes and metabolism without affecting graft-versus-tumor activity.

Organic Electrochemical Transistor as an On-site Signal Amplifier for Electrochemical Aptamer-based Sensing

This paper demonstrates an organic electrochemical transistor (OECT) as an on-site amplifier for electrochemical aptamer-based sensors, significantly enhancing sensitivity for TGF-β1 detection.

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

Gut Microbiome Contributes to Cold-climate Adaptation in Lizards

The paper investigates how gut microbiota contributes to cold-climate adaptation in two lizard species, finding species-specific differences in microbial composition and metabolic gene abundance.

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

Research on the temporal evolution track and influence of green development in the last decade

This paper evaluates the temporal evolution of green development in Baoshan, Yunnan Province, using statistical models to analyze trends, subsystem interactions, and influencing factors.

Human KIR+CD8+ T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19

The paper identifies KIR+CD8+ T cells as regulatory cells in humans that suppress pathogenic CD4+ T cells in autoimmune and infectious diseases.

A magnetic field prevents alcoholic liver disease by reducing oxidative stress

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

A MYB transcription factor, PlMYB308, plays an essential role in flower senescence of herbaceous peony

This study identifies PlMYB308 as a key regulator of flower senescence in herbaceous peony by modulating hormone levels and anthocyanin biosynthesis.

SAFA facilitates chromatin opening of immune genes through interacting with nascent antiviral RNAs

This study shows SAFA interacts with antiviral RNAs to open chromatin and enhance immune gene expression during viral infection.