Cell BiologybioRxivPreprint
Involvement of I-BAR protein IRSp53 in tumor cell growth via extracellular microvesicle secretion
H. T. Hu, N. Sasakura, D. Matsubara…·S. Suetsugu
This study shows IRSp53 promotes tumor cell proliferation through microvesicle secretion, as evidenced by reduced secretion and phosphorylation in knockout cells and increased survival in IRSp53-deficient mice.