Author

K. Ratia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Lavie· 1 shared B. P. Przychodzen· 1 shared B. S. Prabhakar· 1 shared D. Kong· 1 shared F. Huang· 1 shared G. Birznieks· 1 shared G. R. J. Thatcher· 1 shared G. R. Thatcher· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Lavie

Author profile →

3 papers

Recent·Most cited

Dual Inhibition of Cathepsin L and 3CL-Pro by GC-376 Constrains SARS Cov2 Infection Including Omicron Variant

B. S. Prabhakar, P. Kumar, K. Ratia, J. M. Richner, G. R. J. Thatcher, R. Kadam, S. P. Smieszek, B. P. Przychodzen, V. Koprivica, G. Birznieks, M. H. Polymeropoulos

This study shows that dual inhibition of cathepsin-L and 3CL-Pro by GC-376 effectively inhibits SARS-CoV-2 infection, including the Omicron variant, in highly susceptible cell lines.

bioRxiv · Feb 9, 2022 · PreprintMicrobiology

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

Z. Shen, K. Ratia, L. Cooper, D. Kong, H. Lee, Y. Kwon, Y. Li, S. Alqarni, F. Huang, O. Dubrovskyi, L. Rong, G. R. Thatcher, R. XIONG

This study identifies potent non-covalent SARS-CoV-2 PLpro inhibitors that block viral replication in human and monkey cell cultures with low nanomolar potency.

bioRxiv · Feb 13, 2021Microbiology

Identifying small molecule probes of ENTPD5 through high throughput screening

M. A. Durst, K. Ratia, A. Lavie

This study identifies two small molecule inhibitors of ENTPD5 through high-throughput screening and validates their effect on glycoprotein production in prostate cancer cells.

bioRxiv · Dec 21, 2018Biochemistry