R. Xiong

This study uses 3D bioprinting to create nasal epithelium models from patient-derived cells, enabling high-throughput fabrication and recapitulating native epithelial architecture and virus infection capability.

This study identifies the mechanism by which NAMPT is activated by positive allosteric modulators, revealing how this enhances NAD+ biosynthesis and regulates NAM binding.

This study evaluates the effectiveness of molecular fingerprints in identifying active drugs during virtual screening and finds they lack discriminative power between active and inactive molecules.

This study uses multi-omics analyses to compare short- and long-term ME/CFS patients with healthy controls, identifying microbiome and metabolic differences and potential biomarkers.

This study identifies potent non-covalent SARS-CoV-2 PLpro inhibitors that block viral replication in human and monkey cell cultures with low nanomolar potency.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.