Y. Kwon

Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.

Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as novel inhibitor for ELF3-MED23 Interaction

This study synthesizes and evaluates chalcone and pyrazoline derivatives as ELF3-MED23 PPI inhibitors, showing compound 10 effectively reduces HER2 levels and induces apoptosis in HER2-positive gastric cancer cells.

Identification and Analysis of SARS-CoV-2 Mutation and Subtype using 2x tiled Primer Set with Oxford Nanopore Technologies Sequencing for Enhanced Variant Detection and Surveillance in Seoul, Korea

The paper uses long-read sequencing with a 2x tiled primer set to identify SARS-CoV-2 mutations and subtypes in Seoul, Korea, showing improved variant detection and genotype-patient characteristic correlation.

Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller

This study visualizes the chaperone-mediated folding trajectory of Gβ5 using cryo-EM, showing how CCT stabilizes intermediates to fold the β-propeller domain.

Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs

This study demonstrates that minimally immunogenic Cas9 RNPs delivered via convection enhanced delivery can edit mouse striatal neurons with reduced immune responses compared to AAV-delivered Cas9.

A new protocol for speed vernalisation of winter cereals

This paper introduces a new vernalisation protocol that significantly reduces generation time for winter cereals by combining extended photoperiod and low-temperature exposure with speed breeding conditions.

RAD51AP1 and RAD54 underpin two distinct RAD51-dependent routes of DNA damage repair via homologous recombination

This study identifies RAD51AP1 and RAD54 as two distinct RAD51-dependent HR sub-pathways, showing their combined inactivation enhances cancer cell sensitivity to DNA damage agents.

Genomic consequences of domestication of the Siamese fighting fish

The paper uses genomic data to show betta fish were domesticated over 1,000 years ago and identifies genes involved in their phenotypic diversity.

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

This study identifies potent non-covalent SARS-CoV-2 PLpro inhibitors that block viral replication in human and monkey cell cultures with low nanomolar potency.

Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination

This study shows Rad55-Rad57 acts as a molecular chaperone in HR by facilitating Rad51 filament reassembly after Srs2 disruption.

Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells

This study shows that SARS-CoV-2 RNA can enter cardiomyocytes via extracellular vesicles from infected lung cells, leading to inflammation-related gene upregulation.

Structural Basis of CD4 Downregulation by HIV-1 Nef

This paper presents a high-resolution crystal structure of HIV-1 Nef interacting with AP2, revealing how Nef sequesters CD4 for degradation and identifying a dual-function pocket crucial for both MHC recruitment and CD4 binding.

PARP1 and MGMT interaction-based sensitivity to DNA damage in Ewing sarcoma

This study shows that PARP1 and MGMT interact and work epistatically to repair DNA damage in Ewing sarcoma, suggesting potential for improved DNA-damaging therapies.

Clathrin-coated Pits are Shredded Organelles Presorting Receptors in the Plasma Membrane

The paper shows clathrin-coated pits pre-sort receptors on the plasma membrane to modulate their activation, with EGFR and TfR using mutually exclusive CCP subsets.

Loop-mediated isothermal amplification assay for Enterococcus sp., E. coli and S. aureus in chicken

The paper develops LAMP assays for detecting Enterococcus sp., E. coli, and S. aureus in chicken to diagnose bacterial chondronecrosis with osteomyelitis.