Cancer BiologybioRxiv
Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death
R. Avelar, A. Armstrong, G. Carvette…·A. DiFeo
This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.
DOI 10.1158/1535-7163.mct-21-0880