A. Armstrong

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

Comparative population genomics of manta rays has global implications for management

This study uses comparative population genomics to show that oceanic manta rays have higher genetic diversity and connectivity than reef manta rays, with implications for conservation management.

Emergent dynamics of underlying regulatory network links EMT and androgen receptor-dependent resistance in prostate cancer

The paper models a regulatory network linking EMT and AR resistance in prostate cancer, identifying four phenotypes and showing stochastic switching between states.

Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

Acrylamide Fragment Inhibitors that Induce Unprecedented Conformational Distortions in Enterovirus 71 3C and SARS-CoV-2 Main Protease

The paper identifies acrylamide fragments that covalently inhibit EV71 3Cpro and SARS-CoV-2 Mpro by targeting their active site cysteine, inducing conformational changes and allosteric effects.

A novel female-specific circadian clock mechanism regulating metabolism

This study identifies a female-specific circadian clock mechanism involving Siah2 that regulates metabolic rhythms and gene expression in the liver.

The hearing aid dilemma: amplification, compression, and distortion of the neural code

This study identifies that hearing aids restore neural sensitivity but reduce selectivity due to compression and amplification, which distort the neural code even with normal hearing.