ImmunologybioRxiv
The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state and its deletion improves checkpoint blockade
S. E. McClory, O. Bardhan, K. S. Rome…·M. S. Jordan
This study shows that deleting Trib1 shifts exhausted T cells to a KLR+ CD8+ effector state, enhancing viral clearance and checkpoint inhibitor response.