Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses
M. S. Strine, W. L. Cai, J. Wei, M. M. Alfajaro, R. B. Filler, S. B. Biering, S. Sarnik, A. Patil, K. S. Cervantes, C. K. Collings, P. C. DeWeirdt, R. E. Hanna, K. Schofield, C. Hulme, S. Konermann, , C. B. Wilen
This study shows DYRK1A promotes viral entry of SARS-CoV, SARS-CoV-2, and MERS-CoV by regulating ACE2 and DPP4 transcription without its kinase activity.
bioRxiv · Sep 13, 2022 · PreprintMicrobiology