A. Patil

Single-molecule Mapping of Amyloid-β Oligomer Insertion intoLipid Bilayers

This study uses QSLIP to map amyloid-beta oligomer membrane insertion, finding toxicity correlates with amino-terminal penetration depth.

Functional characterization of two glycosyltransferases from Withania somnifera illuminates their role in withanosides biosynthesis and defence against bacteria

This study functionally characterizes two glycosyltransferases in Ashwagandha, showing their roles in withanoside biosynthesis and defense against bacterial pathogens.

Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation

The paper uses mouse models to map sepsis' effects across organs, identifying cytokine circuits and PLA2G5's role in hemolysis and organ failure.

BRCA1 expression, its correlation with clinicopathological features and response to neoadjuvant chemotherapy in high grade serous ovarian cancer from an Indian centre

How woodcocks produce the most brilliant white plumage patches among the birds

The paper explains how Eurasian woodcocks produce exceptionally bright white plumage patches through nanostructural and macrostructural light scattering mechanisms.

Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses

This study shows DYRK1A promotes viral entry of SARS-CoV, SARS-CoV-2, and MERS-CoV by regulating ACE2 and DPP4 transcription without its kinase activity.

Deterministic Early Endosomal Maturations Emerge From a Stochastic Trigger-and-Convert Mechanism

The paper tracks endosomal maturation events using advanced imaging and simulations, revealing that maturation is driven by heterotypic EEA1-mediated interactions rather than autonomous stochastic processes.

In vivo augmentation of a complex gut bacterial community

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

Systematic dissection of a complex gut bacterial community

This study constructs a defined gut bacterial community of 104 strains and investigates strain-strain and strain-nutrient interactions through amino acid dropout experiments.

Rapid Whole Cell Imaging Reveals A Calcium-APPL1-Dynein Nexus That Regulates Cohort Trafficking of Stimulated EGF Receptor

The paper uses whole-cell imaging to reveal a calcium-APPL1-dynein mechanism that directs EGFR trafficking to the peri-nuclear region.

Combination of photoactivation with lattice light-sheet imaging reveals untemplated, lamellar ruffle generation by PA-Rac1

The paper uses optogenetic PA-Rac1 and lattice light-sheet imaging to show Rac1 drives untemplated lamellar ruffle formation without a template.

Genome-wide CRISPR Screens Reveal Genetic Mediators of Cereblon Modulator Toxicity in Primary Effusion Lymphoma

The paper uses CRISPR screens to identify genetic mediators of cereblon modulator toxicity in primary effusion lymphoma, finding that CRBN and UBE2G1 inactivation confer resistance to different CMs.

E74 like ETS transcription factor 3 (ELF3) is a negative regulator of epithelial-mesenchymal transition in bladder carcinoma

This study shows ELF3 suppresses epithelial-mesenchymal transition in bladder cancer by reducing mesenchymal markers and invasion.