Author

C. Kadoch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. G. Doench· 2 shared S. L. Schreiber· 2 shared A. B. Haynes· 1 shared A. J. Church· 1 shared A. L. Hong· 1 shared A. Patil· 1 shared A. R. Richman· 1 shared A. Regev· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

J. G. Doench

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Highly specific intracellular ubiquitination of a small molecule

W. Li, E. M. Garcia-Rivera, D. C. Mitchell, J. M. Chick, M. Maetani, J. M. Knapp, G. M. Matthews, R. Shirasaki, R. de Matos Simoes, V. Viswanathan, J. L. Pulice, M. G. Rees, J. A. Roth, S. P. Gygi, C. S. Mitsiades, , J. M. L. Ostrem

The paper identifies a small molecule, BRD1732, that is ubiquitinated in cells, leading to proteasome inhibition through accumulation of ubiquitin chains.

bioRxiv · Jan 26, 2024Biochemistry

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

L. Duplaquet, K. So, A. W. Ying, X. Li, Y. Li, X. Qiu, R. Li, S. Singh, X. S. Wu, Q. Liu, J. Qi, T. D. D. Somerville, H. Heiling, E. Mazzola, Y. Lee, , M. G. Oser

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

bioRxiv · Jan 21, 2024Cancer Biology

Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses

M. S. Strine, W. L. Cai, J. Wei, M. M. Alfajaro, R. B. Filler, S. B. Biering, S. Sarnik, A. Patil, K. S. Cervantes, C. K. Collings, P. C. DeWeirdt, R. E. Hanna, K. Schofield, C. Hulme, S. Konermann, , C. B. Wilen

This study shows DYRK1A promotes viral entry of SARS-CoV, SARS-CoV-2, and MERS-CoV by regulating ACE2 and DPP4 transcription without its kinase activity.

bioRxiv · Sep 13, 2022 · PreprintMicrobiology

Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma

L. Jerby, C. Neftel, M. E. Shore, M. J. McBride, B. Haas, B. Izar, H. R. Weissman, A. Volorio, G. Boulay, L. Cironi, A. R. Richman, L. C. Broye, J. M. Gurski, C. C. Luo, R. Mylvaganam, , A. Regev

The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.

bioRxiv · Aug 4, 2019 · PreprintCancer Biology

Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

A. L. Hong, Y.-Y. Tseng, J. A. Wala, W. J. Kim, B. D. Kynnap, M. B. Doshi, G. Kugener, G. J. Sandoval, T. P. Howard, J. Li, X. Yang, M. Tillgren, M. Ghandi, A. Sayeed, R. Deasy, , W. Hahn

This study identifies SMARCB1 loss as critical for RMC survival and shows proteasome inhibition as a potential therapeutic strategy.

bioRxiv · Dec 5, 2018Cancer Biology