Author

K. Snead

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

D. Esposito· 4 shared M. Drew· 4 shared S. Messing· 3 shared V. Wall· 3 shared J. Mehalko· 2 shared J.-P. Denson· 2 shared K. Sadtler· 2 shared T. Taylor· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBiochemistry

D. Esposito

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Flatworm transcriptomes reveal widespread parasitism by histophagous ciliates

M. R. Woodcock, K. Powers, K. Snead, J. Pellettieri

The paper identifies ciliate parasites in flatworms using a novel bioinformatics pipeline and finds evidence of coevolution and potential dispersal mechanisms.

bioRxiv · Sep 17, 2023Evolutionary Biology

Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome

D. A. Bonsor, P. Alexander, K. Snead, N. Hartig, M. Drew, S. Messing, L. I. Finci, D. V. Nissley, F. McCormick, D. Esposito, P. Rodriguez-Viciana, A. G. Stephen, D. K. Simanshu

The paper presents the structure of the SHOC2-MRAS-PP1C complex and shows how it regulates RAF activation and is linked to Noonan syndrome mutations.

bioRxiv · May 10, 2022Biophysics

Polycistronic baculovirus expression of SUGT1 enables high-yield production of recombinantleucine-rich repeat proteins and protein complexes

K. Snead, V. Wall, H. Ambrose, D. Esposito, M. Drew

This paper demonstrates that using SUGT1 chaperone with polycistronic baculovirus expression improves yield and quality of leucine-rich repeat proteins and complexes.

bioRxiv · Jan 19, 2022Biochemistry

Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays

J. Mehalko, M. Drew, K. Snead, J.-P. Denson, V. Wall, T. Taylor, K. Sadtler, S. Messing, W. Gillette, D. Esposito

The paper improves the production of SARS-CoV-2 spike RBD for serology assays by optimizing DNA constructs, purification parameters, and demonstrating the role of a carboxyterminal tag in sensitivity.

bioRxiv · Nov 18, 2020Biochemistry

Optimizing high-yield production of SARS-CoV-2 soluble spike trimers for serology assays

D. Esposito, J. Mehalko, M. Drew, K. Snead, V. Wall, T. Taylor, P. Frank, J.-P. Denson, M. Hong, G. Gulten, K. Sadtler, S. Messing, W. Gillette

This study improves the yield of SARS-CoV-2 spike protein for serology assays by optimizing expression and purification parameters, achieving 5 mg/L production.

bioRxiv · May 27, 2020Biochemistry